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KMID : 0670820090140030127
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Korean Journal of Medical Mycology
2009 Volume.14 No. 3 p.127 ~ p.132
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Antifungal Activity of the Essential oil from Eucalyptus and Eucapytol against Candida albicans
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Seong In-Wha
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Abstract
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Background: Candida albicans is a member of the normal flora of the skin, mucous membranes and gastrointestinal tract. Vaginal candidiasis remains a significant problem in women of childbearing age, majority of the cases are caused by C. albicans and recurrence is common in spite of topical treatment.
Objective: The purpose of this study was to develop the antifungal agent from the medicinal herbs traditionally used in Korea.
Method: In this study, the essential oil of eucalyptus, cedar wood, clary sage, orange sweet and eucapytol were examined for antifungal activities against C. albicans.
Results:
1. Eucalyptus essential oil and eucapytol showed antifungal activity against C. albicans.
2. Minimal inhibitory concentration (MIC) of Eucapytol against eight strains and standard strains was 12.5 μl/ml and 6.25 μl/ml against two strains.
3. MIC of eucapytol was 25 μl/ml against eight strains and 50 μl/ml against two.
Conclusion: Eucalyptus essential oil and eucalytol could be a candidate for a new antifungal agent for candidiasis and other fungal diseases.
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KEYWORD
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Eucalyptus oil, Eucapytol, Antifungal activity, Candida albicans
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